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| 1st(1st leg) | Mamelodi Sundowns | - | Al Ahly SC | 5:0 (2:0) | ||
| 2nd (2nd leg) | Al Ahly SC | - | Mamelodi Sundowns | 1:0 (0:0) | ||
| 1st(1st leg): 06/04/2019 14:00 | 2nd (2nd leg): 13/04/2019 17:00 | Winner: Mamelodi Sundowns | ||||
| 1st(1st leg) | Simba SC | - | TP Mazembe | 0:0 (0:0) | ||
| 2nd (2nd leg) | TP Mazembe | - | Simba SC | 4:1 (2:1) | ||
| 1st(1st leg): 06/04/2019 14:00 | 2nd (2nd leg): 13/04/2019 14:00 | Winner: TP Mazembe | ||||
| 1st(1st leg) | Horoya AC | - | Wydad AC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Wydad AC | - | Horoya AC | 5:0 (3:0) | ||
| 1st(1st leg): 06/04/2019 17:00 | 2nd (2nd leg): 13/04/2019 20:00 | Winner: Wydad AC | ||||
| 1st(1st leg) | CS Constantine | - | Espérance de Tunis | 2:3 (0:1) | ||
| 2nd (2nd leg) | Espérance de Tunis | - | CS Constantine | 3:1 (2:0) | ||
| 1st(1st leg): 06/04/2019 20:00 | 2nd (2nd leg): 13/04/2019 20:00 | Winner: Espérance de Tunis | ||||
