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| 1st(1st leg) | Horoya AC | - | Al Ahly SC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Al Ahly SC | - | Horoya AC | 4:0 (1:0) | ||
| 1st(1st leg): 14/09/2018 17:00 | 2nd (2nd leg): 22/09/2018 20:00 | Winner: Al Ahly SC | ||||
| 1st(1st leg) | ES Sétif | - | Wydad AC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Wydad AC | - | ES Sétif | 0:0 (0:0) | ||
| 1st(1st leg): 14/09/2018 20:00 | 2nd (2nd leg): 21/09/2018 20:00 | Winner: ES Sétif | ||||
| 1st(1st leg) | CD 1º de Agosto | - | TP Mazembe | 0:0 (0:0) | ||
| 2nd (2nd leg) | TP Mazembe | - | CD 1º de Agosto | 1:1 (1:1) | ||
| 1st(1st leg): 15/09/2018 17:00 | 2nd (2nd leg): 21/09/2018 14:00 | Winner: CD 1º de Agosto | ||||
| 1st(1st leg) | Espérance de Tunis | - | Étoile du Sahel | 2:1 (1:1) | ||
| 2nd (2nd leg) | Étoile du Sahel | - | Espérance de Tunis | 0:1 (0:0) | ||
| 1st(1st leg): 15/09/2018 20:00 | 2nd (2nd leg): 21/09/2018 17:00 | Winner: Espérance de Tunis | ||||
