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| 1st(1st leg) | Zamalek | - | Espérance de Tunis | 3:1 (1:1) | ||
| 2nd (2nd leg) | Espérance de Tunis | - | Zamalek | 1:0 (1:0) | ||
| 1st(1st leg): 28/02/2020 16:00 | 2nd (2nd leg): 06/03/2020 19:00 | Winner: Zamalek | ||||
| 1st(1st leg) | Raja Casablanca | - | TP Mazembe | 2:0 (1:0) | ||
| 2nd (2nd leg) | TP Mazembe | - | Raja Casablanca | 1:0 (0:0) | ||
| 1st(1st leg): 28/02/2020 19:00 | 2nd (2nd leg): 07/03/2020 13:00 | Winner: Raja Casablanca | ||||
| 1st(1st leg) | Al Ahly SC | - | Mamelodi Sundowns | 2:0 (0:0) | ||
| 2nd (2nd leg) | Mamelodi Sundowns | - | Al Ahly SC | 1:1 (1:1) | ||
| 1st(1st leg): 29/02/2020 16:00 | 2nd (2nd leg): 07/03/2020 13:00 | Winner: Al Ahly SC | ||||
| 1st(1st leg) | Wydad AC | - | Étoile du Sahel | 2:0 (1:0) | ||
| 2nd (2nd leg) | Étoile du Sahel | - | Wydad AC | 1:0 (0:0) | ||
| 1st(1st leg): 29/02/2020 19:00 | 2nd (2nd leg): 07/03/2020 19:00 | Winner: Wydad AC | ||||
