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| 1st(1st leg) | Petro Atlético | - | Wydad AC | 1:3 (0:2) | ||
| 2nd (2nd leg) | Wydad AC | - | Petro Atlético | 1:1 (1:1) | ||
| 1st(1st leg): 07/05/2022 14:00 | 2nd (2nd leg): 13/05/2022 20:00 | Winner: Wydad AC | ||||
| 1st(1st leg) | Al Ahly SC | - | ES Sétif | 4:0 (1:0) | ||
| 2nd (2nd leg) | ES Sétif | - | Al Ahly SC | 2:2 (1:1) | ||
| 1st(1st leg): 07/05/2022 20:00 | 2nd (2nd leg): 14/05/2022 20:00 | Winner: Al Ahly SC | ||||
