1st(1st leg) Odense BK - Lokomotiv Sofia 2:2 (2:0)
2nd (2nd leg) Lokomotiv Sofia - Odense BK 2:1 (1:1)
1st(1st leg): 13/09/1978 2nd (2nd leg): 27/09/1978 Winner: Lokomotiv Sofia
1st(1st leg) Partizan - Dynamo Dresden 2:0 (1:0)
2nd (2nd leg) Dynamo Dresden - Partizan 5:4 (1:0, 2:0, 2:0) pso
1st(1st leg): 13/09/1978 2nd (2nd leg): 27/09/1978 16:00 Winner: Dynamo Dresden
1st(1st leg) TJ Zbrojovka Brno - Újpesti Dózsa SC 2:2 (0:1)
2nd (2nd leg) Újpesti Dózsa SC - TJ Zbrojovka Brno 0:2 (0:2)
1st(1st leg): 13/09/1978 15:00 2nd (2nd leg): 27/09/1978 16:45 Winner: TJ Zbrojovka Brno
1st(1st leg) FK Vllaznia - Austria Wien 2:0 (1:0)
2nd (2nd leg) Austria Wien - FK Vllaznia 4:1 (2:0)
1st(1st leg): 13/09/1978 15:30 2nd (2nd leg): 27/09/1978 17:00 Winner: Austria Wien
1st(1st leg) Linfield FC - Lillestrøm SK 0:0 (0:0)
2nd (2nd leg) Lillestrøm SK - Linfield FC 1:0 (1:0)
1st(1st leg): 13/09/1978 17:30 2nd (2nd leg): 27/09/1978 18:00 Winner: Lillestrøm SK
1st(1st leg) Haka Valkeakoski - Dinamo Kiev 0:1 (0:0)
2nd (2nd leg) Dinamo Kiev - Haka Valkeakoski 3:1 (2:0)
1st(1st leg): 13/09/1978 18:00 2nd (2nd leg): 27/09/1978 17:00 Winner: Dinamo Kiev
1st(1st leg) Malmö FF - AS Monaco 0:0 (0:0)
2nd (2nd leg) AS Monaco - Malmö FF 0:1 (0:1)
1st(1st leg): 13/09/1978 18:00 2nd (2nd leg): 27/09/1978 Winner: Malmö FF
1st(1st leg) Nottingham Forest - Liverpool FC 2:0 (1:0)
2nd (2nd leg) Liverpool FC - Nottingham Forest 0:0 (0:0)
1st(1st leg): 13/09/1978 18:30 2nd (2nd leg): 27/09/1978 19:30 Winner: Nottingham Forest
1st(1st leg) Omonia Nikosia - Bohemian FC 2:1 (1:1)
2nd (2nd leg) Bohemian FC - Omonia Nikosia 1:0 (1:0)
1st(1st leg): 13/09/1978 18:30 2nd (2nd leg): 27/09/1978 15:00 Winner: Bohemian FC
1st(1st leg) 1. FC Köln - ÍA Akranes 4:1 (3:1)
2nd (2nd leg) ÍA Akranes - 1. FC Köln 1:1 (1:0)
1st(1st leg): 13/09/1978 19:00 2nd (2nd leg): 27/09/1978 17:00 Winner: 1. FC Köln
1st(1st leg) Club Brugge KV - Wisła Kraków 2:1 (2:0)
2nd (2nd leg) Wisła Kraków - Club Brugge KV 3:1 (1:0)
1st(1st leg): 13/09/1978 19:00 2nd (2nd leg): 27/09/1978 16:00 Winner: Wisła Kraków
1st(1st leg) Grasshopper Club Zürich - Valletta FC 8:0 (3:0)
2nd (2nd leg) Valletta FC - Grasshopper Club Zürich 3:5 (0:1)
1st(1st leg): 13/09/1978 19:00 2nd (2nd leg): 27/09/1978 14:30 Winner: Grasshopper Club Zürich
1st(1st leg) Fenerbahçe - PSV Eindhoven 2:1 (2:1)
2nd (2nd leg) PSV Eindhoven - Fenerbahçe 6:1 (2:0)
1st(1st leg): 13/09/1978 19:30 2nd (2nd leg): 27/09/1978 19:00 Winner: PSV Eindhoven
1st(1st leg) Juventus - Rangers FC 1:0 (1:0)
2nd (2nd leg) Rangers FC - Juventus 2:0 (1:0)
1st(1st leg): 13/09/1978 19:30 2nd (2nd leg): 27/09/1978 18:30 Winner: Rangers FC
1st(1st leg) Real Madrid - Progrès Niedercorn 5:0 (3:0)
2nd (2nd leg) Progrès Niedercorn - Real Madrid 0:7 (0:3)
1st(1st leg): 13/09/1978 20:00 2nd (2nd leg): 27/09/1978 19:00 Winner: Real Madrid
1st(1st leg) AEK Athen - FC Porto 6:1 (4:0)
2nd (2nd leg) FC Porto - AEK Athen 4:1 (0:1)
1st(1st leg): 13/09/1978 20:00 2nd (2nd leg): 27/09/1978 21:45 Winner: AEK Athen