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| 1st(1st leg) | Progrès Niedercorn | - | Glentoran FC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Glentoran FC | - | Progrès Niedercorn | 4:0 (1:0) | ||
| 1st(1st leg): 16/09/1981 | 2nd (2nd leg): 30/09/1981 | Winner: Glentoran FC | ||||
| 1st(1st leg) | Hibernians FC | - | Crvena Zvezda | 1:2 (1:0) | ||
| 2nd (2nd leg) | Crvena Zvezda | - | Hibernians FC | 8:1 (5:0) | ||
| 1st(1st leg): 16/09/1981 15:45 | 2nd (2nd leg): 30/09/1981 14:00 | Winner: Crvena Zvezda | ||||
| 1st(1st leg) | Widzew Łódź | - | RSC Anderlecht | 1:4 (0:1) | ||
| 2nd (2nd leg) | RSC Anderlecht | - | Widzew Łódź | 2:1 (1:0) | ||
| 1st(1st leg): 16/09/1981 16:00 | 2nd (2nd leg): 30/09/1981 19:00 | Winner: RSC Anderlecht | ||||
| 1st(1st leg) | FC Universitatea Craiova | - | Olympiakos Piraeus | 3:0 (1:0) | ||
| 2nd (2nd leg) | Olympiakos Piraeus | - | FC Universitatea Craiova | 2:0 (1:0) | ||
| 1st(1st leg): 16/09/1981 16:00 | 2nd (2nd leg): 30/09/1981 18:30 | Winner: FC Universitatea Craiova | ||||
| 1st(1st leg) | Dinamo Kiev | - | Trabzonspor | 1:0 (0:0) | ||
| 2nd (2nd leg) | Trabzonspor | - | Dinamo Kiev | 1:1 (1:0) | ||
| 1st(1st leg): 16/09/1981 17:00 | 2nd (2nd leg): 30/09/1981 13:00 | Winner: Dinamo Kiev | ||||
| 1st(1st leg) | OPS Oulu | - | Liverpool FC | 0:1 (0:0) | ||
| 2nd (2nd leg) | Liverpool FC | - | OPS Oulu | 7:0 (2:0) | ||
| 1st(1st leg): 16/09/1981 17:30 | 2nd (2nd leg): 30/09/1981 17:30 | Winner: Liverpool FC | ||||
| 1st(1st leg) | Ferencvárosi TC | - | TJ Baník Ostrava OKD | 3:2 (2:0) | ||
| 2nd (2nd leg) | TJ Baník Ostrava OKD | - | Ferencvárosi TC | 3:0 (2:0) | ||
| 1st(1st leg): 16/09/1981 18:00 | 2nd (2nd leg): 30/09/1981 16:00 | Winner: TJ Baník Ostrava OKD | ||||
| 1st(1st leg) | KB København | - | Athlone Town | 1:1 (1:1) | ||
| 2nd (2nd leg) | Athlone Town | - | KB København | 2:2 (0:1) | ||
| 1st(1st leg): 16/09/1981 18:00 | 2nd (2nd leg): 30/09/1981 | Winner: KB København | ||||
| 1st(1st leg) | CSKA Sofia | - | Real Sociedad | 1:0 (0:0) | ||
| 2nd (2nd leg) | Real Sociedad | - | CSKA Sofia | 0:0 (0:0) | ||
| 1st(1st leg): 16/09/1981 18:00 | 2nd (2nd leg): 30/09/1981 19:00 | Winner: CSKA Sofia | ||||
| 1st(1st leg) | Celtic FC | - | Juventus | 1:0 (0:0) | ||
| 2nd (2nd leg) | Juventus | - | Celtic FC | 2:0 (2:0) | ||
| 1st(1st leg): 16/09/1981 18:30 | 2nd (2nd leg): 30/09/1981 19:30 | Winner: Juventus | ||||
| 1st(1st leg) | IK Start | - | AZ '67 Alkmaar | 1:3 (0:2) | ||
| 2nd (2nd leg) | AZ '67 Alkmaar | - | IK Start | 1:0 (0:0) | ||
| 1st(1st leg): 16/09/1981 18:30 | 2nd (2nd leg): 30/09/1981 19:15 | Winner: AZ '67 Alkmaar | ||||
| 1st(1st leg) | Aston Villa | - | Valur Reykjavík | 5:0 (3:0) | ||
| 2nd (2nd leg) | Valur Reykjavík | - | Aston Villa | 0:2 (0:1) | ||
| 1st(1st leg): 16/09/1981 18:30 | 2nd (2nd leg): 30/09/1981 | Winner: Aston Villa | ||||
| 1st(1st leg) | Östers IF | - | Bayern München | 0:1 (0:0) | ||
| 2nd (2nd leg) | Bayern München | - | Östers IF | 5:0 (3:0) | ||
| 1st(1st leg): 16/09/1981 18:30 | 2nd (2nd leg): 30/09/1981 19:00 | Winner: Bayern München | ||||
| 1st(1st leg) | BFC Dynamo | - | FC Zürich | 2:0 (0:0) | ||
| 2nd (2nd leg) | FC Zürich | - | BFC Dynamo | 3:1 (2:0) | ||
| 1st(1st leg): 16/09/1981 19:00 | 2nd (2nd leg): 30/09/1981 19:00 | Winner: BFC Dynamo | ||||
| 1st(1st leg) | Austria Wien | - | FK Partizani | 3:1 (1:1) | ||
| 2nd (2nd leg) | FK Partizani | - | Austria Wien | 1:0 (1:0) | ||
| 1st(1st leg): 16/09/1981 19:00 | 2nd (2nd leg): 30/09/1981 15:00 | Winner: Austria Wien | ||||
| 1st(1st leg) | SL Benfica | - | Omonia Nikosia | 3:0 (0:0) | ||
| 2nd (2nd leg) | Omonia Nikosia | - | SL Benfica | 0:1 (0:0) | ||
| 1st(1st leg): 16/09/1981 20:00 | 2nd (2nd leg): 30/09/1981 19:30 | Winner: SL Benfica | ||||
