1st(1st leg) Odense BK - Real Madrid 1:4 (1:2)
2nd (2nd leg) Real Madrid - Odense BK 6:0 (2:0)
1st(1st leg): 18/09/1990 2nd (2nd leg): 02/10/1990 Winner: Real Madrid
1st(1st leg) Valletta FC - Rangers FC 0:4 (0:1)
2nd (2nd leg) Rangers FC - Valletta FC 6:0 (4:0)
1st(1st leg): 19/09/1990 2nd (2nd leg): 02/10/1990 Winner: Rangers FC
1st(1st leg) APOEL Nikosia - Bayern München 2:3 (1:0)
2nd (2nd leg) Bayern München - APOEL Nikosia 4:0 (0:0)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: Bayern München
1st(1st leg) Lech Poznań - Panathinaikos 3:0 (2:0)
2nd (2nd leg) Panathinaikos - Lech Poznań 1:2 (1:0)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: Lech Poznań
1st(1st leg) Dinamo Bucureşti - St Patrick's Athletic 4:0 (3:0)
2nd (2nd leg) St Patrick's Athletic - Dinamo Bucureşti 1:1 (1:0)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: Dinamo Bucureşti
1st(1st leg) TJ Sparta Praha - Spartak Moskva 0:2 (0:1)
2nd (2nd leg) Spartak Moskva - TJ Sparta Praha 2:0 (1:0)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: Spartak Moskva
1st(1st leg) Crvena Zvezda - Grasshopper Club Zürich 1:1 (1:1)
2nd (2nd leg) Grasshopper Club Zürich - Crvena Zvezda 1:4 (0:1)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: Crvena Zvezda
1st(1st leg) Lillestrøm SK - Club Brugge KV 1:1 (0:1)
2nd (2nd leg) Club Brugge KV - Lillestrøm SK 2:0 (1:0)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: Club Brugge KV
1st(1st leg) FC Porto - Portadown FC 5:0 (3:0)
2nd (2nd leg) Portadown FC - FC Porto 1:8 (1:4)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: FC Porto
1st(1st leg) Union Luxembourg - Dynamo Dresden 1:3 (1:0)
2nd (2nd leg) Dynamo Dresden - Union Luxembourg 3:0 (3:0)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: Dynamo Dresden
1st(1st leg) FC Tirol - FC Kuusysi (old) 5:0 (3:0)
2nd (2nd leg) FC Kuusysi (old) - FC Tirol 1:2 (0:1)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: FC Tirol
1st(1st leg) Malmö FF - Beşiktaş 3:2 (1:0)
2nd (2nd leg) Beşiktaş - Malmö FF 2:2 (2:0)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: Malmö FF
1st(1st leg) KA Akureyri - CSKA Sofia 1:0 (1:0)
2nd (2nd leg) CSKA Sofia - KA Akureyri 3:0 (1:0)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: CSKA Sofia
1st(1st leg) SSC Napoli - Újpesti Dózsa SC 3:0 (2:0)
2nd (2nd leg) Újpesti Dózsa SC - SSC Napoli 0:2 (0:2)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: SSC Napoli
1st(1st leg) Olympique Marseille - Dinamo Tiranë 5:1 (1:0)
2nd (2nd leg) Dinamo Tiranë - Olympique Marseille 0:0 (0:0)
1st(1st leg): 19/09/1990 2nd (2nd leg): 03/10/1990 Winner: Olympique Marseille