1st(1st leg) FK Astana - Dinamo Zagreb 0:2 (0:1)
2nd (2nd leg) Dinamo Zagreb - FK Astana 1:0 (0:0)
1st(1st leg): 07/08/2018 15:00 2nd (2nd leg): 14/08/2018 19:00 Winner: Dinamo Zagreb
1st(1st leg) Qarabağ FK - BATE Borisov 0:1 (0:1)
2nd (2nd leg) BATE Borisov - Qarabağ FK 1:1 (1:0)
1st(1st leg): 07/08/2018 18:00 2nd (2nd leg): 14/08/2018 18:00 Winner: BATE Borisov
1st(1st leg) Malmö FF - MOL Vidi FC 1:1 (0:0)
2nd (2nd leg) MOL Vidi FC - Malmö FF 0:0 (0:0)
1st(1st leg): 07/08/2018 18:15 2nd (2nd leg): 14/08/2018 19:00 Winner: MOL Vidi FC
1st(1st leg) Slavia Praha - Dinamo Kiev 1:1 (0:0)
2nd (2nd leg) Dinamo Kiev - Slavia Praha 2:0 (1:0)
1st(1st leg): 07/08/2018 18:30 2nd (2nd leg): 14/08/2018 17:30 Winner: Dinamo Kiev
1st(1st leg) Standard Liège - AFC Ajax 2:2 (0:2)
2nd (2nd leg) AFC Ajax - Standard Liège 3:0 (2:0)
1st(1st leg): 07/08/2018 19:00 2nd (2nd leg): 14/08/2018 19:30 Winner: AFC Ajax
1st(1st leg) Crvena Zvezda - Spartak Trnava 1:1 (1:1)
2nd (2nd leg) Spartak Trnava - Crvena Zvezda 1:2 (1:1, 1:1) aet
1st(1st leg): 07/08/2018 19:30 2nd (2nd leg): 14/08/2018 19:30 Winner: Crvena Zvezda
1st(1st leg) SL Benfica - Fenerbahçe 1:0 (0:0)
2nd (2nd leg) Fenerbahçe - SL Benfica 1:1 (1:1)
1st(1st leg): 07/08/2018 20:00 2nd (2nd leg): 14/08/2018 19:00 Winner: SL Benfica
1st(1st leg) RB Salzburg - KF Shkëndija 79 3:0 (2:0)
2nd (2nd leg) KF Shkëndija 79 - RB Salzburg 0:1 (0:0)
1st(1st leg): 08/08/2018 18:00 2nd (2nd leg): 14/08/2018 19:15 Winner: RB Salzburg
1st(1st leg) PAOK Saloniki - Spartak Moskva 3:2 (3:2)
2nd (2nd leg) Spartak Moskva - PAOK Saloniki 0:0 (0:0)
1st(1st leg): 08/08/2018 18:00 2nd (2nd leg): 14/08/2018 18:30 Winner: PAOK Saloniki
1st(1st leg) Celtic FC - AEK Athen 1:1 (1:1)
2nd (2nd leg) AEK Athen - Celtic FC 2:1 (1:0)
1st(1st leg): 08/08/2018 19:45 2nd (2nd leg): 14/08/2018 19:00 Winner: AEK Athen