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| 1st(1st leg) | Crvena Zvezda | - | RB Salzburg | 0:0 (0:0) | ||
| 2nd (2nd leg) | RB Salzburg | - | Crvena Zvezda | 2:2 (1:0) | ||
| 1st(1st leg): 21/08/2018 20:00 | 2nd (2nd leg): 29/08/2018 20:00 | Winner: Crvena Zvezda | ||||
| 1st(1st leg) | BATE Borisov | - | PSV Eindhoven | 2:3 (1:1) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | BATE Borisov | 3:0 (2:0) | ||
| 1st(1st leg): 21/08/2018 20:00 | 2nd (2nd leg): 29/08/2018 20:00 | Winner: PSV Eindhoven | ||||
| 1st(1st leg) | SL Benfica | - | PAOK Saloniki | 1:1 (1:0) | ||
| 2nd (2nd leg) | PAOK Saloniki | - | SL Benfica | 1:4 (1:3) | ||
| 1st(1st leg): 21/08/2018 20:00 | 2nd (2nd leg): 29/08/2018 20:00 | Winner: SL Benfica | ||||
| 1st(1st leg) | BSC Young Boys | - | Dinamo Zagreb | 1:1 (1:1) | ||
| 2nd (2nd leg) | Dinamo Zagreb | - | BSC Young Boys | 1:2 (1:0) | ||
| 1st(1st leg): 22/08/2018 20:00 | 2nd (2nd leg): 28/08/2018 20:00 | Winner: BSC Young Boys | ||||
| 1st(1st leg) | MOL Vidi FC | - | AEK Athen | 1:2 (0:1) | ||
| 2nd (2nd leg) | AEK Athen | - | MOL Vidi FC | 1:1 (0:0) | ||
| 1st(1st leg): 22/08/2018 20:00 | 2nd (2nd leg): 28/08/2018 20:00 | Winner: AEK Athen | ||||
| 1st(1st leg) | AFC Ajax | - | Dinamo Kiev | 3:1 (3:1) | ||
| 2nd (2nd leg) | Dinamo Kiev | - | AFC Ajax | 0:0 (0:0) | ||
| 1st(1st leg): 22/08/2018 20:00 | 2nd (2nd leg): 28/08/2018 20:00 | Winner: AFC Ajax | ||||
