1st(1st leg) Slavia Praha - FC Midtjylland 0:0 (0:0)
2nd (2nd leg) FC Midtjylland - Slavia Praha 4:1 (0:1)
1st(1st leg): 22/09/2020 20:00 2nd (2nd leg): 30/09/2020 20:00 Winner: FC Midtjylland
1st(1st leg) Maccabi Tel Aviv - RB Salzburg 1:2 (1:0)
2nd (2nd leg) RB Salzburg - Maccabi Tel Aviv 3:1 (2:1)
1st(1st leg): 22/09/2020 20:00 2nd (2nd leg): 30/09/2020 20:00 Winner: RB Salzburg
1st(1st leg) FK Krasnodar - PAOK Saloniki 2:1 (1:1)
2nd (2nd leg) PAOK Saloniki - FK Krasnodar 1:2 (0:0)
1st(1st leg): 22/09/2020 20:00 2nd (2nd leg): 30/09/2020 20:00 Winner: FK Krasnodar
1st(1st leg) Olympiakos Piraeus - Omonia Nikosia 2:0 (0:0)
2nd (2nd leg) Omonia Nikosia - Olympiakos Piraeus 0:0 (0:0)
1st(1st leg): 23/09/2020 20:00 2nd (2nd leg): 29/09/2020 20:00 Winner: Olympiakos Piraeus
1st(1st leg) Molde FK - Ferencvárosi TC 3:3 (0:1)
2nd (2nd leg) Ferencvárosi TC - Molde FK 0:0 (0:0)
1st(1st leg): 23/09/2020 20:00 2nd (2nd leg): 29/09/2020 20:00 Winner: Ferencvárosi TC
1st(1st leg) KAA Gent - Dinamo Kiev 1:2 (1:1)
2nd (2nd leg) Dinamo Kiev - KAA Gent 3:0 (2:0)
1st(1st leg): 23/09/2020 20:00 2nd (2nd leg): 29/09/2020 20:00 Winner: Dinamo Kiev