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| 1st(1st leg) | Malmö FF | - | Rangers FC | 2:1 (0:0) | ||
| 2nd (2nd leg) | Rangers FC | - | Malmö FF | 1:2 (1:0) | ||
| 1st(1st leg): 03/08/2021 18:00 | 2nd (2nd leg): 10/08/2021 20:00 | Winner: Malmö FF | ||||
| 1st(1st leg) | AC Sparta Praha | - | AS Monaco | 0:2 (0:1) | ||
| 2nd (2nd leg) | AS Monaco | - | AC Sparta Praha | 3:1 (0:0) | ||
| 1st(1st leg): 03/08/2021 18:00 | 2nd (2nd leg): 10/08/2021 19:00 | Winner: AS Monaco | ||||
| 1st(1st leg) | CFR Cluj | - | BSC Young Boys | 1:1 (1:0) | ||
| 2nd (2nd leg) | BSC Young Boys | - | CFR Cluj | 3:1 (3:1) | ||
| 1st(1st leg): 03/08/2021 19:00 | 2nd (2nd leg): 10/08/2021 19:30 | Winner: BSC Young Boys | ||||
| 1st(1st leg) | PSV Eindhoven | - | FC Midtjylland | 3:0 (3:0) | ||
| 2nd (2nd leg) | FC Midtjylland | - | PSV Eindhoven | 0:1 (0:0) | ||
| 1st(1st leg): 03/08/2021 19:00 | 2nd (2nd leg): 10/08/2021 19:00 | Winner: PSV Eindhoven | ||||
| 1st(1st leg) | KRC Genk | - | Shakhtar Donetsk | 1:2 (1:0) | ||
| 2nd (2nd leg) | Shakhtar Donetsk | - | KRC Genk | 2:1 (1:0) | ||
| 1st(1st leg): 03/08/2021 19:00 | 2nd (2nd leg): 10/08/2021 18:30 | Winner: Shakhtar Donetsk | ||||
| 1st(1st leg) | Olympiakos Piraeus | - | PFC Ludogorets Razgrad | 1:1 (0:0) | ||
| 2nd (2nd leg) | PFC Ludogorets Razgrad | - | Olympiakos Piraeus | 4:1 (0:1, 2:2, 2:2) pso | ||
| 1st(1st leg): 03/08/2021 20:00 | 2nd (2nd leg): 10/08/2021 19:00 | Winner: PFC Ludogorets Razgrad | ||||
| 1st(1st leg) | Crvena Zvezda | - | FC Sheriff | 1:1 (1:1) | ||
| 2nd (2nd leg) | FC Sheriff | - | Crvena Zvezda | 1:0 (1:0) | ||
| 1st(1st leg): 03/08/2021 20:00 | 2nd (2nd leg): 10/08/2021 18:00 | Winner: FC Sheriff | ||||
| 1st(1st leg) | Spartak Moskva | - | SL Benfica | 0:2 (0:0) | ||
| 2nd (2nd leg) | SL Benfica | - | Spartak Moskva | 2:0 (0:0) | ||
| 1st(1st leg): 04/08/2021 18:00 | 2nd (2nd leg): 10/08/2021 20:00 | Winner: SL Benfica | ||||
| 1st(1st leg) | Dinamo Zagreb | - | Legia Warszawa | 1:1 (0:0) | ||
| 2nd (2nd leg) | Legia Warszawa | - | Dinamo Zagreb | 0:1 (0:1) | ||
| 1st(1st leg): 04/08/2021 19:00 | 2nd (2nd leg): 10/08/2021 20:00 | Winner: Dinamo Zagreb | ||||
| 1st(1st leg) | Ferencvárosi TC | - | Slavia Praha | 2:0 (1:0) | ||
| 2nd (2nd leg) | Slavia Praha | - | Ferencvárosi TC | 1:0 (1:0) | ||
| 1st(1st leg): 04/08/2021 19:00 | 2nd (2nd leg): 10/08/2021 18:00 | Winner: Ferencvárosi TC | ||||
