1st(1st leg) Santiago Morning - Cobreloa 0:0 (0:0)
2nd (2nd leg) Cobreloa - Santiago Morning 1:0 (0:0)
1st(1st leg): 16/08/2022 20:00 2nd (2nd leg): 20/08/2022 20:45 Winner: Cobreloa
1st(1st leg) Audax Italiano - Universidad Católica 0:2 (0:1)
2nd (2nd leg) Universidad Católica - Audax Italiano 3:0 (2:0)
1st(1st leg): 16/08/2022 23:00 2nd (2nd leg): 20/08/2022 23:30 Winner: Universidad Católica
1st(1st leg) Universidad de Concepción - CD Magallanes 0:2 (0:0)
2nd (2nd leg) CD Magallanes - Universidad de Concepción 4:1 (3:1)
1st(1st leg): 17/08/2022 01:30 2nd (2nd leg): 20/08/2022 18:15 Winner: CD Magallanes
1st(1st leg) Antofagasta - Curicó Unido 4:2 (1:0)
2nd (2nd leg) Curicó Unido - Antofagasta 2:1 (2:1)
1st(1st leg): 17/08/2022 22:00 2nd (2nd leg): 21/08/2022 17:00 Winner: Antofagasta
1st(1st leg) Ñublense - Colo-Colo 2:1 (0:0)
2nd (2nd leg) Colo-Colo - Ñublense 1:1 (0:0)
1st(1st leg): 17/08/2022 23:00 2nd (2nd leg): 21/08/2022 22:30 Winner: Ñublense
1st(1st leg) O'Higgins - Unión Española 1:3 (1:0)
2nd (2nd leg) Unión Española - O'Higgins 1:0 (0:0)
1st(1st leg): 18/08/2022 01:30 2nd (2nd leg): 22/08/2022 01:00 Winner: Unión Española
1st(1st leg) Huachipato - Coquimbo Unido 1:0 (1:0)
2nd (2nd leg) Coquimbo Unido - Huachipato 0:0 (0:0)
1st(1st leg): 18/08/2022 23:00 2nd (2nd leg): 23/08/2022 01:30 Winner: Huachipato
1st(1st leg) Cobresal - Universidad de Chile 1:1 (0:1)
2nd (2nd leg) Universidad de Chile - Cobresal 1:0 (1:0)
1st(1st leg): 19/08/2022 01:30 2nd (2nd leg): 22/08/2022 23:00 Winner: Universidad de Chile