1st(1st leg) Santiago Morning - Deportes Temuco 1:1 (0:0)
2nd (2nd leg) Deportes Temuco - Santiago Morning 2:1 (1:0)
1st(1st leg): 25/11/2021 21:00 2nd (2nd leg): 01/12/2021 23:30 Winner: Deportes Temuco
1st(1st leg) Puerto Montt - Copiapó 0:1 (0:0)
2nd (2nd leg) Copiapó - Puerto Montt 2:2 (2:0)
1st(1st leg): 25/11/2021 23:30 2nd (2nd leg): 01/12/2021 20:45 Winner: Copiapó