1st(1st leg) La Serena - Colo-Colo 2:6 (2:3)
2nd (2nd leg) Colo-Colo - La Serena 3:1 (1:1)
1st(1st leg): 03/12/2011 19:30 2nd (2nd leg): 10/12/2011 21:15 Winner: Colo-Colo
1st(1st leg) Universidad Católica - Audax Italiano 3:1 (2:0)
2nd (2nd leg) Audax Italiano - Universidad Católica 0:1 (0:1)
1st(1st leg): 03/12/2011 22:00 2nd (2nd leg): 10/12/2011 23:30 Winner: Universidad Católica
1st(1st leg) Unión La Calera - Cobreloa 0:1 (0:1)
2nd (2nd leg) Cobreloa - Unión La Calera 4:3 (1:2)
1st(1st leg): 04/12/2011 19:00 2nd (2nd leg): 11/12/2011 19:00 Winner: Cobreloa
1st(1st leg) Unión Española - Universidad de Chile 0:1 (0:0)
2nd (2nd leg) Universidad de Chile - Unión Española 3:0 (2:0)
1st(1st leg): 04/12/2011 21:30 2nd (2nd leg): 11/12/2011 21:15 Winner: Universidad de Chile