1st(1st leg) Atlético Nacional - Santa Fe 3:0 (2:0)
2nd (2nd leg) Santa Fe - Atlético Nacional 2:0 (0:0)
1st(1st leg): 25/07/2019 01:30 2nd (2nd leg): 16/08/2019 02:00 Winner: Atlético Nacional
1st(1st leg) Rionegro Águilas Doradas - Deportivo Pereira 1:1
2nd (2nd leg) Deportivo Pereira - Rionegro Águilas Doradas 1:0 (1:0)
1st(1st leg): 31/07/2019 22:00 2nd (2nd leg): 14/08/2019 22:00 Winner: Deportivo Pereira
1st(1st leg) Deportivo Cali - Real San Andrés 1:0
2nd (2nd leg) Real San Andrés - Deportivo Cali 0:1
1st(1st leg): 01/08/2019 01:30 2nd (2nd leg): 14/08/2019 21:30 Winner: Deportivo Cali
1st(1st leg) Once Caldas - América de Cali 2:1
2nd (2nd leg) América de Cali - Once Caldas 0:0
1st(1st leg): 01/08/2019 01:30 2nd (2nd leg): 15/08/2019 00:00 Winner: Once Caldas
1st(1st leg) La Equidad - Deportivo Pasto 3:2
2nd (2nd leg) Deportivo Pasto - La Equidad 4:3 pso
1st(1st leg): 01/08/2019 01:30 2nd (2nd leg): 14/08/2019 21:00 Winner: Deportivo Pasto
1st(1st leg) Deportes Tolima - Orsomarso SC 3:0
2nd (2nd leg) Orsomarso SC - Deportes Tolima 0:5
1st(1st leg): 07/08/2019 21:45 2nd (2nd leg): 14/08/2019 21:30 Winner: Deportes Tolima
1st(1st leg) Independiente Medellín - Millonarios 2:1
2nd (2nd leg) Millonarios - Independiente Medellín 2:2
1st(1st leg): 08/08/2019 01:30 2nd (2nd leg): 15/08/2019 02:00 Winner: Independiente Medellín
1st(1st leg) Atlético Junior - Atlético Bucaramanga 2:0
2nd (2nd leg) Atlético Bucaramanga - Atlético Junior 1:2 (1:1)
1st(1st leg): 09/08/2019 01:30 2nd (2nd leg): 16/08/2019 00:00 Winner: Atlético Junior