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| 1st(1st leg) | Real Cartagena | - | Tigres FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Tigres FC | - | Real Cartagena | 1:1 (1:0, 5:3) pso | ||
| 1st(1st leg): 24/09/2020 00:00 | 2nd (2nd leg): 01/10/2020 00:00 | Winner: Real Cartagena | ||||
| 1st(1st leg) | Leones FC | - | Unión Magdalena | 1:1 (1:0) | ||
| 2nd (2nd leg) | Unión Magdalena | - | Leones FC | 1:3 (0:2) | ||
| 1st(1st leg): 24/09/2020 02:05 | 2nd (2nd leg): 02/10/2020 01:45 | Winner: Leones FC | ||||
| 1st(1st leg) | Atlético Huila | - | Real San Andrés | 1:1 (0:1) | ||
| 2nd (2nd leg) | Real San Andrés | - | Atlético Huila | 2:0 (2:0) | ||
| 1st(1st leg): 24/09/2020 21:15 | 2nd (2nd leg): 01/10/2020 21:15 | Winner: Real San Andrés | ||||
| 1st(1st leg) | Fortaleza FC | - | Deportes Quindío | 0:1 (0:0) | ||
| 2nd (2nd leg) | Deportes Quindío | - | Fortaleza FC | 1:0 (0:0) | ||
| 1st(1st leg): 25/09/2020 01:40 | 2nd (2nd leg): 01/10/2020 23:30 | Winner: Deportes Quindío | ||||
