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| 1st(1st leg) | Deportes Tolima | - | Deportivo Pereira | 0:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Pereira | - | Deportes Tolima | 5:4 (0:1, 1:1, 1:1) pso | ||
| 1st(1st leg): 07/10/2021 00:00 | 2nd (2nd leg): 20/10/2021 23:30 | Winner: Deportivo Pereira | ||||
| 1st(1st leg) | Deportivo Cali | - | Atlético Nacional | 2:2 (2:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Deportivo Cali | 1:0 (0:0) | ||
| 1st(1st leg): 07/10/2021 02:00 | 2nd (2nd leg): 22/10/2021 02:00 | Winner: Atlético Nacional | ||||
