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| 1st(1st leg) | Atlético Nacional | - | Deportivo Pereira | 5:0 (2:0) | ||
| 2nd (2nd leg) | Deportivo Pereira | - | Atlético Nacional | 1:0 (0:0) | ||
| 1st(1st leg): 11/11/2021 01:00 | 2nd (2nd leg): 25/11/2021 01:00 | Winner: Atlético Nacional | ||||
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| 1st(1st leg) | Atlético Nacional | - | Deportivo Pereira | 5:0 (2:0) | ||
| 2nd (2nd leg) | Deportivo Pereira | - | Atlético Nacional | 1:0 (0:0) | ||
| 1st(1st leg): 11/11/2021 01:00 | 2nd (2nd leg): 25/11/2021 01:00 | Winner: Atlético Nacional | ||||
