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| 1st(1st leg) | Atlético Junior | - | Unión Magdalena | 0:1 (0:1) | ||
| 2nd (2nd leg) | Unión Magdalena | - | Atlético Junior | 0:1 (0:0, 0:1, 3:5) pso | ||
| 1st(1st leg): 25/08/2022 00:00 | 2nd (2nd leg): 15/09/2022 00:00 | Winner: Atlético Junior | ||||
| 1st(1st leg) | Independiente Medellín | - | Millonarios | 0:2 (0:2) | ||
| 2nd (2nd leg) | Millonarios | - | Independiente Medellín | 2:2 (0:2) | ||
| 1st(1st leg): 25/08/2022 02:05 | 2nd (2nd leg): 08/09/2022 02:00 | Winner: Millonarios | ||||
