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| 1st(1st leg) | La Equidad | - | Deportivo Cali | 1:1 (0:1) | ||
| 2nd (2nd leg) | Deportivo Cali | - | La Equidad | 0:1 (0:0) | ||
| 1st(1st leg): 21/11/2020 22:30 | 2nd (2nd leg): 28/11/2020 22:30 | Winner: La Equidad | ||||
| 1st(1st leg) | América de Cali | - | Atlético Nacional | 1:2 (1:1) | ||
| 2nd (2nd leg) | Atlético Nacional | - | América de Cali | 0:3 (0:2) | ||
| 1st(1st leg): 22/11/2020 01:00 | 2nd (2nd leg): 29/11/2020 01:00 | Winner: América de Cali | ||||
| 1st(1st leg) | Atlético Junior | - | Deportes Tolima | 1:0 (1:0) | ||
| 2nd (2nd leg) | Deportes Tolima | - | Atlético Junior | 0:1 (0:0) | ||
| 1st(1st leg): 22/11/2020 23:05 | 2nd (2nd leg): 30/11/2020 01:00 | Winner: Atlético Junior | ||||
| 1st(1st leg) | Deportivo Pasto | - | Santa Fe | 1:0 (1:0) | ||
| 2nd (2nd leg) | Santa Fe | - | Deportivo Pasto | 2:0 (2:0) | ||
| 1st(1st leg): 23/11/2020 01:10 | 2nd (2nd leg): 29/11/2020 22:30 | Winner: Santa Fe | ||||
