1st(1st leg) Atlético Nacional - Deportes Tolima 3:1 (1:1)
2nd (2nd leg) Deportes Tolima - Atlético Nacional 2:1 (2:0)
1st(1st leg): 23/06/2022 02:00 2nd (2nd leg): 27/06/2022 01:00 Winner: Atlético Nacional