1st(1st leg) Columbus Crew - Real Salt Lake 0:0 (0:0)
2nd (2nd leg) Real Salt Lake - Columbus Crew 4:1 (2:0)
1st(1st leg): 23/02/2011 01:00 2nd (2nd leg): 02/03/2011 03:00 Winner: Real Salt Lake
1st(1st leg) Cruz Azul - Santos Laguna 2:0 (0:0)
2nd (2nd leg) Santos Laguna - Cruz Azul 1:3 (0:1)
1st(1st leg): 23/02/2011 03:00 2nd (2nd leg): 02/03/2011 01:00 Winner: Cruz Azul
1st(1st leg) Deportivo Toluca - CF Monterrey 0:1 (0:0)
2nd (2nd leg) CF Monterrey - Deportivo Toluca 1:0 (0:0)
1st(1st leg): 24/02/2011 01:00 2nd (2nd leg): 03/03/2011 01:00 Winner: CF Monterrey
1st(1st leg) Deportivo Saprissa - Olimpia 1:0 (1:0)
2nd (2nd leg) Olimpia - Deportivo Saprissa 1:2 (0:1)
1st(1st leg): 25/02/2011 01:00 2nd (2nd leg): 04/03/2011 01:00 Winner: Deportivo Saprissa