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| 1st(1st leg) | Deportivo Saprissa | - | UANL Tigres | 1:0 (0:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Deportivo Saprissa | 5:1 (4:1) | ||
| 1st(1st leg): 20/02/2019 01:00 | 2nd (2nd leg): 27/02/2019 03:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Independiente de La Chorrera | - | Toronto FC | 4:0 (1:0) | ||
| 2nd (2nd leg) | Toronto FC | - | Independiente de La Chorrera | 1:1 (1:0) | ||
| 1st(1st leg): 20/02/2019 01:00 | 2nd (2nd leg): 27/02/2019 01:00 | Winner: Independiente de La Chorrera | ||||
| 1st(1st leg) | Deportivo Guastatoya | - | Houston Dynamo | 0:1 (0:0) | ||
| 2nd (2nd leg) | Houston Dynamo | - | Deportivo Guastatoya | 2:1 (0:0) | ||
| 1st(1st leg): 20/02/2019 03:00 | 2nd (2nd leg): 27/02/2019 02:30 | Winner: Houston Dynamo | ||||
| 1st(1st leg) | Marathón | - | Santos Laguna | 2:6 (0:3) | ||
| 2nd (2nd leg) | Santos Laguna | - | Marathón | 5:0 (3:0) | ||
| 1st(1st leg): 21/02/2019 01:00 | 2nd (2nd leg): 28/02/2019 01:00 | Winner: Santos Laguna | ||||
| 1st(1st leg) | CD Pantoja | - | New York RB | 0:2 (0:1) | ||
| 2nd (2nd leg) | New York RB | - | CD Pantoja | 3:0 (2:0) | ||
| 1st(1st leg): 21/02/2019 01:00 | 2nd (2nd leg): 28/02/2019 01:00 | Winner: New York RB | ||||
| 1st(1st leg) | Alianza | - | CF Monterrey | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Alianza | 1:0 (0:0) | ||
| 1st(1st leg): 21/02/2019 03:00 | 2nd (2nd leg): 28/02/2019 03:00 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Sporting Kansas City | - | Deportivo Toluca | 3:0 (1:0) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | Sporting Kansas City | 0:2 (0:1) | ||
| 1st(1st leg): 22/02/2019 01:00 | 2nd (2nd leg): 01/03/2019 03:00 | Winner: Sporting Kansas City | ||||
| 1st(1st leg) | CS Herediano | - | Atlanta United FC | 3:1 (2:1) | ||
| 2nd (2nd leg) | Atlanta United FC | - | CS Herediano | 4:0 (2:0) | ||
| 1st(1st leg): 22/02/2019 03:00 | 2nd (2nd leg): 01/03/2019 01:00 | Winner: Atlanta United FC | ||||
