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| 1st(1st leg) | UANL Tigres | - | Santos Laguna | 3:0 (3:0) | ||
| 2nd (2nd leg) | Santos Laguna | - | UANL Tigres | 3:2 (1:2) | ||
| 1st(1st leg): 04/04/2019 03:00 | 2nd (2nd leg): 11/04/2019 01:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | CF Monterrey | - | Sporting Kansas City | 5:0 (2:0) | ||
| 2nd (2nd leg) | Sporting Kansas City | - | CF Monterrey | 2:5 (2:2) | ||
| 1st(1st leg): 05/04/2019 03:00 | 2nd (2nd leg): 12/04/2019 02:00 | Winner: CF Monterrey | ||||
