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| 1st(1st leg) | New York RB | - | Santos Laguna | 0:2 (0:1) | ||
| 2nd (2nd leg) | Santos Laguna | - | New York RB | 4:2 (0:2) | ||
| 1st(1st leg): 06/03/2019 01:00 | 2nd (2nd leg): 13/03/2019 01:00 | Winner: Santos Laguna | ||||
| 1st(1st leg) | Houston Dynamo | - | UANL Tigres | 0:2 (0:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Houston Dynamo | 1:0 (0:0) | ||
| 1st(1st leg): 06/03/2019 03:00 | 2nd (2nd leg): 13/03/2019 03:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Independiente de La Chorrera | - | Sporting Kansas City | 2:1 (1:0) | ||
| 2nd (2nd leg) | Sporting Kansas City | - | Independiente de La Chorrera | 3:0 (0:0) | ||
| 1st(1st leg): 07/03/2019 01:00 | 2nd (2nd leg): 15/03/2019 00:00 | Winner: Sporting Kansas City | ||||
| 1st(1st leg) | CF Monterrey | - | Atlanta United FC | 3:0 (1:0) | ||
| 2nd (2nd leg) | Atlanta United FC | - | CF Monterrey | 1:0 (0:0) | ||
| 1st(1st leg): 07/03/2019 03:00 | 2nd (2nd leg): 14/03/2019 00:00 | Winner: CF Monterrey | ||||
