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| 1st(1st leg) | Impact de Montréal | - | Olimpia | 1:2 (0:2) | ||
| 2nd (2nd leg) | Olimpia | - | Impact de Montréal | 0:1 (0:0) | ||
| 1st(1st leg): 11/03/2020 00:00 | 2nd (2nd leg): 16/12/2020 01:00 | Winner: Olimpia | ||||
| 1st(1st leg) | New York City FC | - | UANL Tigres | 0:1 (0:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | New York City FC | 4:0 (1:0) | ||
| 1st(1st leg): 12/03/2020 00:00 | 2nd (2nd leg): 16/12/2020 03:30 | Winner: UANL Tigres | ||||
| 1st(1st leg) | CF América | - | Atlanta United FC | 3:0 (3:0) | ||
| 2nd (2nd leg) | Atlanta United FC | - | CF América | 1:0 (0:0) | ||
| 1st(1st leg): 12/03/2020 02:30 | 2nd (2nd leg): 17/12/2020 01:00 | Winner: CF América | ||||
| 1st(1st leg) | Los Angeles FC | - | Cruz Azul | 2:1 (1:1) | ||
| 2nd (2nd leg) | Cruz Azul | - | Los Angeles FC | dnp | ||
| 1st(1st leg): 17/12/2020 03:30 | 2nd (2nd leg): 16/12/2020 | Winner: Los Angeles FC | ||||
