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| 1st(1st leg) | Santa Tecla FC | - | AD San Carlos | 0:0 (0:0) | ||
| 2nd (2nd leg) | AD San Carlos | - | Santa Tecla FC | 4:2 (0:0, 0:0) pso | ||
| 1st(1st leg): 21/08/2019 01:00 | 2nd (2nd leg): 28/08/2019 03:00 | Winner: AD San Carlos | ||||
| 1st(1st leg) | SV Robinhood | - | Independiente de La Chorrera | 1:1 (0:0) | ||
| 2nd (2nd leg) | Independiente de La Chorrera | - | SV Robinhood | 2:1 (2:0) | ||
| 1st(1st leg): 21/08/2019 01:00 | 2nd (2nd leg): 28/08/2019 01:00 | Winner: Independiente de La Chorrera | ||||
| 1st(1st leg) | Managua FC | - | Motagua | 1:2 (0:1) | ||
| 2nd (2nd leg) | Motagua | - | Managua FC | 1:1 (1:1) | ||
| 1st(1st leg): 21/08/2019 03:00 | 2nd (2nd leg): 28/08/2019 03:00 | Winner: Motagua | ||||
| 1st(1st leg) | Comunicaciones | - | Deportivo Guastatoya | 2:1 (0:1) | ||
| 2nd (2nd leg) | Deportivo Guastatoya | - | Comunicaciones | 0:0 (0:0) | ||
| 1st(1st leg): 22/08/2019 01:00 | 2nd (2nd leg): 29/08/2019 01:00 | Winner: Comunicaciones | ||||
| 1st(1st leg) | Deportivo Saprissa | - | CD Águila | 2:0 (2:0) | ||
| 2nd (2nd leg) | CD Águila | - | Deportivo Saprissa | 1:0 (0:0) | ||
| 1st(1st leg): 22/08/2019 03:00 | 2nd (2nd leg): 29/08/2019 03:00 | Winner: Deportivo Saprissa | ||||
| 1st(1st leg) | Waterhouse FC | - | CS Herediano | 1:1 (1:1) | ||
| 2nd (2nd leg) | CS Herediano | - | Waterhouse FC | 6:7 (1:1, 1:1) pso | ||
| 1st(1st leg): 22/08/2019 23:00 | 2nd (2nd leg): 30/08/2019 03:00 | Winner: Waterhouse FC | ||||
| 1st(1st leg) | Forge FC | - | Olimpia | 1:0 (1:0) | ||
| 2nd (2nd leg) | Olimpia | - | Forge FC | 4:1 (2:0) | ||
| 1st(1st leg): 23/08/2019 01:00 | 2nd (2nd leg): 30/08/2019 03:00 | Winner: Olimpia | ||||
| 1st(1st leg) | Alianza | - | Tauro FC | 2:0 (1:0) | ||
| 2nd (2nd leg) | Tauro FC | - | Alianza | 1:0 (1:0) | ||
| 1st(1st leg): 23/08/2019 03:00 | 2nd (2nd leg): 30/08/2019 01:00 | Winner: Alianza | ||||
