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| 1st(1st leg) | Real Estelí FC | - | Santa Tecla FC | 2:1 (1:1) | ||
| 2nd (2nd leg) | Santa Tecla FC | - | Real Estelí FC | 1:0 (1:0) | ||
| 1st(1st leg): 31/07/2019 03:00 | 2nd (2nd leg): 07/08/2019 03:00 | Winner: Santa Tecla FC | ||||
| 1st(1st leg) | SV Robinhood | - | AS Capoise Cap Haitien | 0:0 (0:0) | ||
| 2nd (2nd leg) | AS Capoise Cap Haitien | - | SV Robinhood | 1:1 (1:0) | ||
| 1st(1st leg): 01/08/2019 01:00 | 2nd (2nd leg): 08/08/2019 01:00 | Winner: SV Robinhood | ||||
| 1st(1st leg) | Belmopan Bandits | - | Deportivo Saprissa | 1:3 (1:3) | ||
| 2nd (2nd leg) | Deportivo Saprissa | - | Belmopan Bandits | 3:1 (0:1) | ||
| 1st(1st leg): 01/08/2019 03:00 | 2nd (2nd leg): 08/08/2019 03:00 | Winner: Deportivo Saprissa | ||||
| 1st(1st leg) | Forge FC | - | Antigua GFC | 2:1 (0:1) | ||
| 2nd (2nd leg) | Antigua GFC | - | Forge FC | 0:0 (0:0) | ||
| 1st(1st leg): 01/08/2019 23:00 | 2nd (2nd leg): 09/08/2019 01:00 | Winner: Forge FC | ||||
| 1st(1st leg) | Alianza | - | San Francisco FC | 5:1 (3:1) | ||
| 2nd (2nd leg) | San Francisco FC | - | Alianza | 0:1 (0:0) | ||
| 1st(1st leg): 02/08/2019 01:00 | 2nd (2nd leg): 09/08/2019 01:00 | Winner: Alianza | ||||
| 1st(1st leg) | Comunicaciones | - | Marathón | 2:1 (0:1) | ||
| 2nd (2nd leg) | Marathón | - | Comunicaciones | 1:1 (0:0) | ||
| 1st(1st leg): 02/08/2019 03:00 | 2nd (2nd leg): 09/08/2019 03:00 | Winner: Comunicaciones | ||||
