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| 1st(1st leg) | Deportivo Guastatoya | - | Comunicaciones | 0:1 (0:0) | ||
| 2nd (2nd leg) | Comunicaciones | - | Deportivo Guastatoya | 2:1 (0:0) | ||
| 1st(1st leg): 24/11/2021 03:00 | 2nd (2nd leg): 01/12/2021 03:00 | Winner: Comunicaciones | ||||
| 1st(1st leg) | Forge FC | - | Motagua | 2:2 (0:1) | ||
| 2nd (2nd leg) | Motagua | - | Forge FC | 0:0 (0:0) | ||
| 1st(1st leg): 25/11/2021 01:00 | 2nd (2nd leg): 02/12/2021 01:00 | Winner: Motagua | ||||
