1st(1st leg) Real España - LD Alajuelense 0:3 (0:1)
2nd (2nd leg) LD Alajuelense - Real España 2:2 (1:1)
1st(1st leg): 05/10/2022 02:00 2nd (2nd leg): 12/10/2022 01:00 Winner: LD Alajuelense
1st(1st leg) Motagua - Olimpia 0:0 (0:0)
2nd (2nd leg) Olimpia - Motagua 1:0 (0:0)
1st(1st leg): 06/10/2022 02:00 2nd (2nd leg): 12/10/2022 03:15 Winner: Olimpia