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| 1st(1st leg) | Cobreloa | - | Rosario Central | 2:3 (1:1) | ||
| 2nd (2nd leg) | Rosario Central | - | Cobreloa | 1:1 (1:0) | ||
| 1st(1st leg): 08/05/2001 | 2nd (2nd leg): 15/05/2001 | Winner: Rosario Central | ||||
| 1st(1st leg) | El Nacional | - | Cruzeiro | 1:2 (0:1) | ||
| 2nd (2nd leg) | Cruzeiro | - | El Nacional | 4:1 (2:1) | ||
| 1st(1st leg): 08/05/2001 | 2nd (2nd leg): 15/05/2001 | Winner: Cruzeiro | ||||
| 1st(1st leg) | América de Cali | - | Nacional | 2:0 (0:0) | ||
| 2nd (2nd leg) | Nacional | - | América de Cali | 1:3 (0:2) | ||
| 1st(1st leg): 09/05/2001 | 2nd (2nd leg): 17/05/2001 | Winner: América de Cali | ||||
| 1st(1st leg) | São Caetano - SP | - | Palmeiras | 1:0 (0:0) | ||
| 2nd (2nd leg) | Palmeiras | - | São Caetano - SP | 5:3 (0:0, 1:0, 1:0) pso | ||
| 1st(1st leg): 09/05/2001 | 2nd (2nd leg): 16/05/2001 | Winner: Palmeiras | ||||
| 1st(1st leg) | Emelec | - | River Plate | 2:0 (1:0) | ||
| 2nd (2nd leg) | River Plate | - | Emelec | 5:0 (2:0) | ||
| 1st(1st leg): 09/05/2001 | 2nd (2nd leg): 17/05/2001 | Winner: River Plate | ||||
| 1st(1st leg) | Deportes Concepción | - | Vasco da Gama - RJ | 1:3 (1:1) | ||
| 2nd (2nd leg) | Vasco da Gama - RJ | - | Deportes Concepción | 1:0 (0:0) | ||
| 1st(1st leg): 09/05/2001 | 2nd (2nd leg): 16/05/2001 | Winner: Vasco da Gama - RJ | ||||
| 1st(1st leg) | Cerro Porteño | - | Cruz Azul | 2:1 (1:1) | ||
| 2nd (2nd leg) | Cruz Azul | - | Cerro Porteño | 3:1 (3:1) | ||
| 1st(1st leg): 10/05/2001 | 2nd (2nd leg): 16/05/2001 | Winner: Cruz Azul | ||||
| 1st(1st leg) | Atlético Junior | - | Boca Juniors | 2:3 (2:1) | ||
| 2nd (2nd leg) | Boca Juniors | - | Atlético Junior | 1:1 (1:1) | ||
| 1st(1st leg): 10/05/2001 | 2nd (2nd leg): 16/05/2001 | Winner: Boca Juniors | ||||
