1st(1st leg) Atlético Junior - Boca Juniors 3:3 (3:1)
2nd (2nd leg) Boca Juniors - Atlético Junior 4:0 (2:0)
1st(1st leg): 18/05/2005 00:15 2nd (2nd leg): 26/05/2005 23:05 Winner: Boca Juniors
1st(1st leg) LDU Quito - River Plate 2:1 (1:1)
2nd (2nd leg) River Plate - LDU Quito 4:2 (2:0)
1st(1st leg): 18/05/2005 02:30 2nd (2nd leg): 27/05/2005 01:15 Winner: River Plate
1st(1st leg) Banfield - Independiente Medellín 3:0 (0:0)
2nd (2nd leg) Independiente Medellín - Banfield 0:2 (0:0)
1st(1st leg): 18/05/2005 23:20 2nd (2nd leg): 25/05/2005 01:00 Winner: Banfield
1st(1st leg) Palmeiras - São Paulo FC 0:1 (0:0)
2nd (2nd leg) São Paulo FC - Palmeiras 2:0 (0:0)
1st(1st leg): 19/05/2005 01:40 2nd (2nd leg): 26/05/2005 00:15 Winner: São Paulo FC
1st(1st leg) CF Pachuca - Deportivo Guadalajara 1:1 (1:0)
2nd (2nd leg) Deportivo Guadalajara - CF Pachuca 3:1 (1:1)
1st(1st leg): 19/05/2005 03:50 2nd (2nd leg): 25/05/2005 03:30 Winner: Deportivo Guadalajara
1st(1st leg) Athletico Paranaense - Cerro Porteño 2:1 (1:0)
2nd (2nd leg) Cerro Porteño - Athletico Paranaense 4:5 (2:1, 2:1, 2:1) pso
1st(1st leg): 19/05/2005 23:15 2nd (2nd leg): 26/05/2005 22:15 Winner: Athletico Paranaense
1st(1st leg) Universidad de Chile - Santos FC 2:1 (0:0)
2nd (2nd leg) Santos FC - Universidad de Chile 3:0 (1:0)
1st(1st leg): 20/05/2005 01:30 2nd (2nd leg): 25/05/2005 23:45 Winner: Santos FC
1st(1st leg) Once Caldas - UANL Tigres 1:1 (0:1)
2nd (2nd leg) UANL Tigres - Once Caldas 2:1 (0:1)
1st(1st leg): 20/05/2005 03:45 2nd (2nd leg): 27/05/2005 03:45 Winner: UANL Tigres