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| 1st(1st leg) | Lanús | - | Atlas Guadalajara | 0:1 (0:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Lanús | 2:2 (1:0) | ||
| 1st(1st leg): 30/04/2008 00:10 | 2nd (2nd leg): 07/05/2008 03:30 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | LDU Quito | - | Estudiantes | 2:0 (0:0) | ||
| 2nd (2nd leg) | Estudiantes | - | LDU Quito | 2:1 (0:1) | ||
| 1st(1st leg): 30/04/2008 02:30 | 2nd (2nd leg): 07/05/2008 01:00 | Winner: LDU Quito | ||||
| 1st(1st leg) | Boca Juniors | - | Cruzeiro | 2:1 (1:0) | ||
| 2nd (2nd leg) | Cruzeiro | - | Boca Juniors | 1:2 (0:2) | ||
| 1st(1st leg): 30/04/2008 21:40 | 2nd (2nd leg): 07/05/2008 23:10 | Winner: Boca Juniors | ||||
| 1st(1st leg) | San Lorenzo | - | River Plate | 2:1 (1:1) | ||
| 2nd (2nd leg) | River Plate | - | San Lorenzo | 2:2 (1:0) | ||
| 1st(1st leg): 30/04/2008 23:45 | 2nd (2nd leg): 09/05/2008 00:30 | Winner: San Lorenzo | ||||
| 1st(1st leg) | CF América | - | Flamengo RJ | 2:4 (1:1) | ||
| 2nd (2nd leg) | Flamengo RJ | - | CF América | 0:3 (0:2) | ||
| 1st(1st leg): 30/04/2008 23:45 | 2nd (2nd leg): 08/05/2008 01:50 | Winner: CF América | ||||
| 1st(1st leg) | Atlético Nacional | - | Fluminense RJ | 1:2 (0:1) | ||
| 2nd (2nd leg) | Fluminense RJ | - | Atlético Nacional | 1:0 (0:0) | ||
| 1st(1st leg): 01/05/2008 02:00 | 2nd (2nd leg): 06/05/2008 22:30 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | Nacional | - | São Paulo FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | São Paulo FC | - | Nacional | 2:0 (1:0) | ||
| 1st(1st leg): 01/05/2008 02:00 | 2nd (2nd leg): 08/05/2008 01:50 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Santos FC | - | Cúcuta Deportivo | 2:0 (1:0) | ||
| 2nd (2nd leg) | Cúcuta Deportivo | - | Santos FC | 0:2 (0:1) | ||
| 1st(1st leg): 02/05/2008 00:45 | 2nd (2nd leg): 09/05/2008 03:15 | Winner: Santos FC | ||||
