1st(1st leg) Deportivo Táchira - Libertad 1:0 (1:0)
2nd (2nd leg) Libertad - Deportivo Táchira 3:1 (1:1)
1st(1st leg): 26/01/2010 2nd (2nd leg): 02/02/2010 Winner: Libertad
1st(1st leg) Colón de Santa Fe - Universidad Católica 3:2 (1:1)
2nd (2nd leg) Universidad Católica - Colón de Santa Fe 5:3 (1:0, 3:2, 3:2) pso
1st(1st leg): 26/01/2010 2nd (2nd leg): 09/02/2010 Winner: Universidad Católica
1st(1st leg) Juan Aurich - Estudiantes Tecos 2:0 (1:0)
2nd (2nd leg) Estudiantes Tecos - Juan Aurich 1:2 (0:1)
1st(1st leg): 27/01/2010 2nd (2nd leg): 03/02/2010 Winner: Juan Aurich
1st(1st leg) Real Potosí - Cruzeiro 1:1 (0:1)
2nd (2nd leg) Cruzeiro - Real Potosí 7:0 (3:0)
1st(1st leg): 27/01/2010 2nd (2nd leg): 03/02/2010 Winner: Cruzeiro
1st(1st leg) Newell's Old Boys - Emelec 0:0 (0:0)
2nd (2nd leg) Emelec - Newell's Old Boys 2:1 (0:0)
1st(1st leg): 27/01/2010 2nd (2nd leg): 10/02/2010 Winner: Emelec
1st(1st leg) Atlético Junior - Racing 2:2 (1:1)
2nd (2nd leg) Racing - Atlético Junior 2:0 (1:0)
1st(1st leg): 28/01/2010 2nd (2nd leg): 04/02/2010 Winner: Racing