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| 1st(1st leg) | Real Garcilaso | - | Santa Fe | 1:3 (0:2) | ||
| 2nd (2nd leg) | Santa Fe | - | Real Garcilaso | 2:0 (1:0) | ||
| 1st(1st leg): 22/05/2013 23:45 | 2nd (2nd leg): 29/05/2013 02:00 | Winner: Santa Fe | ||||
| 1st(1st leg) | Fluminense RJ | - | Club Olimpia | 0:0 (0:0) | ||
| 2nd (2nd leg) | Club Olimpia | - | Fluminense RJ | 2:1 (2:1) | ||
| 1st(1st leg): 23/05/2013 02:00 | 2nd (2nd leg): 30/05/2013 02:00 | Winner: Club Olimpia | ||||
| 1st(1st leg) | Club Tijuana | - | Atlético Mineiro | 2:2 (1:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Club Tijuana | 1:1 (1:1) | ||
| 1st(1st leg): 24/05/2013 01:30 | 2nd (2nd leg): 31/05/2013 02:00 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Boca Juniors | - | Newell's Old Boys | 0:0 (0:0) | ||
| 2nd (2nd leg) | Newell's Old Boys | - | Boca Juniors | 10:9 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 24/05/2013 01:30 | 2nd (2nd leg): 29/05/2013 23:30 | Winner: Newell's Old Boys | ||||
