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| 1st(1st leg) | Universitario de Sucre | - | UANL Tigres | 1:2 (1:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Universitario de Sucre | 1:1 (0:1) | ||
| 1st(1st leg): 29/04/2015 01:30 | 2nd (2nd leg): 06/05/2015 03:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Estudiantes | - | Santa Fe | 2:1 (2:0) | ||
| 2nd (2nd leg) | Santa Fe | - | Estudiantes | 2:0 (1:0) | ||
| 1st(1st leg): 06/05/2015 00:45 | 2nd (2nd leg): 13/05/2015 01:30 | Winner: Santa Fe | ||||
| 1st(1st leg) | Guaraní | - | Corinthians SP | 2:0 (0:0) | ||
| 2nd (2nd leg) | Corinthians SP | - | Guaraní | 0:1 (0:0) | ||
| 1st(1st leg): 06/05/2015 23:45 | 2nd (2nd leg): 14/05/2015 02:00 | Winner: Guaraní | ||||
| 1st(1st leg) | Atlético Mineiro | - | Internacional | 2:2 (1:1) | ||
| 2nd (2nd leg) | Internacional | - | Atlético Mineiro | 3:1 (2:0) | ||
| 1st(1st leg): 07/05/2015 02:00 | 2nd (2nd leg): 14/05/2015 02:00 | Winner: Internacional | ||||
| 1st(1st leg) | São Paulo FC | - | Cruzeiro | 1:0 (0:0) | ||
| 2nd (2nd leg) | Cruzeiro | - | São Paulo FC | 4:3 (0:0, 4:3, 4:3) pso | ||
| 1st(1st leg): 07/05/2015 02:00 | 2nd (2nd leg): 13/05/2015 23:30 | Winner: Cruzeiro | ||||
| 1st(1st leg) | Montevideo Wanderers | - | Racing Club | 1:1 (0:0) | ||
| 2nd (2nd leg) | Racing Club | - | Montevideo Wanderers | 2:1 (2:0) | ||
| 1st(1st leg): 07/05/2015 22:45 | 2nd (2nd leg): 14/05/2015 22:30 | Winner: Racing Club | ||||
| 1st(1st leg) | River Plate | - | Boca Juniors | 1:0 (0:0) | ||
| 2nd (2nd leg) | Boca Juniors | - | River Plate | 0:3 dec. | ||
| 1st(1st leg): 08/05/2015 01:00 | 2nd (2nd leg): 15/05/2015 | Winner: River Plate | ||||
| 1st(1st leg) | Emelec | - | Atlético Nacional | 2:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Emelec | 1:0 (0:0) | ||
| 1st(1st leg): 08/05/2015 03:15 | 2nd (2nd leg): 15/05/2015 03:30 | Winner: Emelec | ||||
