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| 1st(1st leg) | Carabobo FC | - | Guaraní | 1:0 (1:0) | ||
| 2nd (2nd leg) | Guaraní | - | Carabobo FC | 6:0 (2:0) | ||
| 1st(1st leg): 30/01/2018 22:15 | 2nd (2nd leg): 06/02/2018 22:15 | Winner: Guaraní | ||||
| 1st(1st leg) | Banfield | - | Independiente del Valle | 1:1 (0:0) | ||
| 2nd (2nd leg) | Independiente del Valle | - | Banfield | 2:2 (1:1) | ||
| 1st(1st leg): 31/01/2018 00:30 | 2nd (2nd leg): 07/02/2018 00:30 | Winner: Banfield | ||||
| 1st(1st leg) | Santiago Wanderers | - | FBC Melgar | 1:1 (1:1) | ||
| 2nd (2nd leg) | FBC Melgar | - | Santiago Wanderers | 0:1 (0:1) | ||
| 1st(1st leg): 31/01/2018 00:30 | 2nd (2nd leg): 07/02/2018 00:30 | Winner: Santiago Wanderers | ||||
| 1st(1st leg) | Chapecoense | - | Nacional | 0:1 (0:0) | ||
| 2nd (2nd leg) | Nacional | - | Chapecoense | 1:0 (1:0) | ||
| 1st(1st leg): 31/01/2018 23:45 | 2nd (2nd leg): 07/02/2018 23:45 | Winner: Nacional | ||||
| 1st(1st leg) | Universidad de Concepción | - | Vasco da Gama - RJ | 0:4 (0:2) | ||
| 2nd (2nd leg) | Vasco da Gama - RJ | - | Universidad de Concepción | 2:0 (2:0) | ||
| 1st(1st leg): 31/01/2018 23:45 | 2nd (2nd leg): 07/02/2018 23:45 | Winner: Vasco da Gama - RJ | ||||
| 1st(1st leg) | Deportivo Táchira | - | Santa Fe | 2:3 (2:2) | ||
| 2nd (2nd leg) | Santa Fe | - | Deportivo Táchira | 0:0 (0:0) | ||
| 1st(1st leg): 01/02/2018 22:15 | 2nd (2nd leg): 09/02/2018 00:00 | Winner: Santa Fe | ||||
| 1st(1st leg) | Oriente Petrolero | - | Jorge Wilstermann | 1:2 (1:0) | ||
| 2nd (2nd leg) | Jorge Wilstermann | - | Oriente Petrolero | 2:2 (2:0) | ||
| 1st(1st leg): 02/02/2018 00:30 | 2nd (2nd leg): 09/02/2018 00:30 | Winner: Jorge Wilstermann | ||||
| 1st(1st leg) | Club Olimpia | - | Atlético Junior | 1:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Junior | - | Club Olimpia | 3:1 (1:1) | ||
| 1st(1st leg): 02/02/2018 00:30 | 2nd (2nd leg): 09/02/2018 02:15 | Winner: Atlético Junior | ||||
