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| 1st(1st leg) | Atlético Tucumán | - | Grêmio Porto Alegre | 0:2 (0:1) | ||
| 2nd (2nd leg) | Grêmio Porto Alegre | - | Atlético Tucumán | 4:0 (2:0) | ||
| 1st(1st leg): 19/09/2018 01:45 | 2nd (2nd leg): 03/10/2018 01:45 | Winner: Grêmio Porto Alegre | ||||
| 1st(1st leg) | Independiente | - | River Plate | 0:0 (0:0) | ||
| 2nd (2nd leg) | River Plate | - | Independiente | 3:1 (0:0) | ||
| 1st(1st leg): 19/09/2018 23:30 | 2nd (2nd leg): 02/10/2018 23:30 | Winner: River Plate | ||||
| 1st(1st leg) | Boca Juniors | - | Cruzeiro | 2:0 (1:0) | ||
| 2nd (2nd leg) | Cruzeiro | - | Boca Juniors | 1:1 (0:0) | ||
| 1st(1st leg): 20/09/2018 01:45 | 2nd (2nd leg): 05/10/2018 01:45 | Winner: Boca Juniors | ||||
| 1st(1st leg) | Colo-Colo | - | Palmeiras | 0:2 (0:1) | ||
| 2nd (2nd leg) | Palmeiras | - | Colo-Colo | 2:0 (1:0) | ||
| 1st(1st leg): 21/09/2018 01:45 | 2nd (2nd leg): 04/10/2018 01:45 | Winner: Palmeiras | ||||
