1st(1st leg) Liverpool - Universidad Catolica 2:1 (0:1)
2nd (2nd leg) Universidad Catolica - Liverpool 3:0 (2:0)
1st(1st leg): 24/02/2021 00:30 2nd (2nd leg): 03/03/2021 00:30 Winner: Universidad Catolica
1st(1st leg) Universidad Cesar Vallejo - Caracas FC 0:0 (0:0)
2nd (2nd leg) Caracas FC - Universidad Cesar Vallejo 2:0 (1:0)
1st(1st leg): 24/02/2021 22:15 2nd (2nd leg): 03/03/2021 22:15 Winner: Caracas FC
1st(1st leg) Royal Pari - Guaraní 1:4 (0:3)
2nd (2nd leg) Guaraní - Royal Pari 1:1 (0:0)
1st(1st leg): 25/02/2021 00:30 2nd (2nd leg): 04/03/2021 00:30 Winner: Guaraní