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| 1st(1st leg) | Emelec | - | Atlético Mineiro | 1:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Emelec | 1:0 (0:0) | ||
| 1st(1st leg): 28/06/2022 23:15 | 2nd (2nd leg): 05/07/2022 23:15 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Corinthians SP | - | Boca Juniors | 0:0 (0:0) | ||
| 2nd (2nd leg) | Boca Juniors | - | Corinthians SP | 5:6 (0:0, 0:0) pso | ||
| 1st(1st leg): 29/06/2022 01:30 | 2nd (2nd leg): 06/07/2022 01:30 | Winner: Corinthians SP | ||||
| 1st(1st leg) | Athletico Paranaense | - | Libertad | 2:1 (2:1) | ||
| 2nd (2nd leg) | Libertad | - | Athletico Paranaense | 1:1 (1:0) | ||
| 1st(1st leg): 29/06/2022 01:30 | 2nd (2nd leg): 06/07/2022 01:30 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Cerro Porteño | - | Palmeiras | 0:3 (0:0) | ||
| 2nd (2nd leg) | Palmeiras | - | Cerro Porteño | 5:0 (1:0) | ||
| 1st(1st leg): 29/06/2022 23:15 | 2nd (2nd leg): 06/07/2022 23:15 | Winner: Palmeiras | ||||
| 1st(1st leg) | Talleres de Córdoba | - | Colón de Santa Fe | 1:1 (0:0) | ||
| 2nd (2nd leg) | Colón de Santa Fe | - | Talleres de Córdoba | 0:2 (0:0) | ||
| 1st(1st leg): 29/06/2022 23:15 | 2nd (2nd leg): 06/07/2022 23:15 | Winner: Talleres de Córdoba | ||||
| 1st(1st leg) | Deportes Tolima | - | Flamengo RJ | 0:1 (0:1) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Deportes Tolima | 7:1 (2:0) | ||
| 1st(1st leg): 30/06/2022 01:30 | 2nd (2nd leg): 07/07/2022 01:30 | Winner: Flamengo RJ | ||||
| 1st(1st leg) | Vélez Sarsfield | - | River Plate | 1:0 (1:0) | ||
| 2nd (2nd leg) | River Plate | - | Vélez Sarsfield | 0:0 (0:0) | ||
| 1st(1st leg): 30/06/2022 01:30 | 2nd (2nd leg): 07/07/2022 01:30 | Winner: Vélez Sarsfield | ||||
| 1st(1st leg) | Fortaleza | - | Estudiantes | 1:1 (0:0) | ||
| 2nd (2nd leg) | Estudiantes | - | Fortaleza | 3:0 (1:0) | ||
| 1st(1st leg): 01/07/2022 01:30 | 2nd (2nd leg): 08/07/2022 01:30 | Winner: Estudiantes | ||||
