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| 1st(1st leg) | Corinthians SP | - | Flamengo RJ | 0:2 (0:1) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Corinthians SP | 1:0 (0:0) | ||
| 1st(1st leg): 03/08/2022 01:30 | 2nd (2nd leg): 10/08/2022 01:30 | Winner: Flamengo RJ | ||||
| 1st(1st leg) | Vélez Sarsfield | - | Talleres de Córdoba | 3:2 (1:0) | ||
| 2nd (2nd leg) | Talleres de Córdoba | - | Vélez Sarsfield | 0:1 (0:0) | ||
| 1st(1st leg): 04/08/2022 01:30 | 2nd (2nd leg): 11/08/2022 01:30 | Winner: Vélez Sarsfield | ||||
| 1st(1st leg) | Atlético Mineiro | - | Palmeiras | 2:2 (1:0) | ||
| 2nd (2nd leg) | Palmeiras | - | Atlético Mineiro | 6:5 (0:0, 0:0) pso | ||
| 1st(1st leg): 04/08/2022 01:30 | 2nd (2nd leg): 11/08/2022 01:30 | Winner: Palmeiras | ||||
| 1st(1st leg) | Athletico Paranaense | - | Estudiantes | 0:0 (0:0) | ||
| 2nd (2nd leg) | Estudiantes | - | Athletico Paranaense | 0:1 (0:0) | ||
| 1st(1st leg): 05/08/2022 01:30 | 2nd (2nd leg): 12/08/2022 01:30 | Winner: Athletico Paranaense | ||||
