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| 1st(1st leg) | Guaraní | - | Cerro Porteño | 1:2 (0:2) | ||
| 2nd (2nd leg) | Cerro Porteño | - | Guaraní | 4:3 (0:2, 1:2, 1:2) pso | ||
| 1st(1st leg): 09/08/2005 | 2nd (2nd leg): 23/08/2005 | Winner: Cerro Porteño | ||||
| 1st(1st leg) | El Nacional | - | LDU Quito | 3:4 (1:2) | ||
| 2nd (2nd leg) | LDU Quito | - | El Nacional | 1:2 (0:1) | ||
| 1st(1st leg): 09/08/2005 | 2nd (2nd leg): 25/08/2005 | Winner: LDU Quito | ||||
| 1st(1st leg) | Universitario de Deportes | - | Alianza Atlético | 1:1 (0:0) | ||
| 2nd (2nd leg) | Alianza Atlético | - | Universitario de Deportes | 4:1 (1:0, 1:1, 1:1) pso | ||
| 1st(1st leg): 10/08/2005 | 2nd (2nd leg): 24/08/2005 | Winner: Alianza Atlético | ||||
| 1st(1st leg) | Universidad de Chile | - | Universidad Católica | 1:2 (1:1) | ||
| 2nd (2nd leg) | Universidad Católica | - | Universidad de Chile | 0:1 (0:0) | ||
| 1st(1st leg): 11/08/2005 | 2nd (2nd leg): 25/08/2005 | Winner: Universidad Católica | ||||
| 1st(1st leg) | The Strongest | - | Bolívar | 2:1 (0:1) | ||
| 2nd (2nd leg) | Bolívar | - | The Strongest | 1:2 (1:0) | ||
| 1st(1st leg): 11/08/2005 | 2nd (2nd leg): 25/08/2005 | Winner: The Strongest | ||||
| 1st(1st leg) | Deportivo Cali | - | Atlético Nacional | 2:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Deportivo Cali | 7:6 (2:0, 2:0, 2:0) pso | ||
| 1st(1st leg): 16/08/2005 | 2nd (2nd leg): 23/08/2005 | Winner: Atlético Nacional | ||||
| 1st(1st leg) | Defensor Sporting | - | Danubio | 2:3 (1:1) | ||
| 2nd (2nd leg) | Danubio | - | Defensor Sporting | 1:3 (1:1) | ||
| 1st(1st leg): 16/08/2005 | 2nd (2nd leg): 23/08/2005 | Winner: Defensor Sporting | ||||
| 1st(1st leg) | Trujillanos FC | - | Mineros de Guayana | 3:1 (0:0) | ||
| 2nd (2nd leg) | Mineros de Guayana | - | Trujillanos FC | 1:2 (1:1) | ||
| 1st(1st leg): 18/08/2005 | 2nd (2nd leg): 23/08/2005 | Winner: Trujillanos FC | ||||
