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| 1st(1st leg) | Deportivo Guadalajara | - | Internacional | 0:2 (0:0) | ||
| 2nd (2nd leg) | Internacional | - | Deportivo Guadalajara | 4:0 (3:0) | ||
| 1st(1st leg): 13/11/2008 00:00 | 2nd (2nd leg): 20/11/2008 00:00 | Winner: Internacional | ||||
| 1st(1st leg) | Argentinos Juniors | - | Estudiantes | 1:1 (0:1) | ||
| 2nd (2nd leg) | Estudiantes | - | Argentinos Juniors | 1:0 (0:0) | ||
| 1st(1st leg): 13/11/2008 23:15 | 2nd (2nd leg): 20/11/2008 23:15 | Winner: Estudiantes | ||||
