 |
 |
|
| 1st(1st leg) | Defensor Sporting | - | Club Olimpia | 2:0 (1:0) | ||
| 2nd (2nd leg) | Club Olimpia | - | Defensor Sporting | 1:1 (0:0) | ||
| 1st(1st leg): 03/08/2010 23:00 | 2nd (2nd leg): 03/09/2010 02:15 | Winner: Defensor Sporting | ||||
| 1st(1st leg) | Deportivo Quito | - | Universidad San Martín | 3:2 (1:0) | ||
| 2nd (2nd leg) | Universidad San Martín | - | Deportivo Quito | 2:1 (0:1) | ||
| 1st(1st leg): 05/08/2010 01:15 | 2nd (2nd leg): 11/08/2010 01:15 | Winner: Universidad San Martín | ||||
| 1st(1st leg) | Atlético Huila | - | Trujillanos FC | 4:1 (3:1) | ||
| 2nd (2nd leg) | Trujillanos FC | - | Atlético Huila | 1:1 (1:1) | ||
| 1st(1st leg): 05/08/2010 03:30 | 2nd (2nd leg): 02/09/2010 02:45 | Winner: Atlético Huila | ||||
| 1st(1st leg) | Universidad Cesar Vallejo | - | Barcelona | 1:2 (1:1) | ||
| 2nd (2nd leg) | Barcelona | - | Universidad Cesar Vallejo | 3:1 (2:1) | ||
| 1st(1st leg): 13/08/2010 01:50 | 2nd (2nd leg): 25/08/2010 02:45 | Winner: Barcelona | ||||
| 1st(1st leg) | Universitario de Sucre | - | Colo-Colo | 2:0 (0:0) | ||
| 2nd (2nd leg) | Colo-Colo | - | Universitario de Sucre | 3:1 (1:1) | ||
| 1st(1st leg): 18/08/2010 00:15 | 2nd (2nd leg): 25/08/2010 23:00 | Winner: Universitario de Sucre | ||||
| 1st(1st leg) | Deportivo Lara | - | Santa Fe | 2:0 (2:0) | ||
| 2nd (2nd leg) | Santa Fe | - | Deportivo Lara | 4:0 (1:0) | ||
| 1st(1st leg): 18/08/2010 02:30 | 2nd (2nd leg): 27/08/2010 03:30 | Winner: Santa Fe | ||||
| 1st(1st leg) | Guaraní | - | River Plate | 2:0 (0:0) | ||
| 2nd (2nd leg) | River Plate | - | Guaraní | 4:2 (1:2) | ||
| 1st(1st leg): 19/08/2010 23:30 | 2nd (2nd leg): 02/09/2010 00:15 | Winner: Guaraní | ||||
| 1st(1st leg) | Universidad de Chile | - | Oriente Petrolero | 2:2 (0:0) | ||
| 2nd (2nd leg) | Oriente Petrolero | - | Universidad de Chile | 1:0 (1:0) | ||
| 1st(1st leg): 25/08/2010 00:15 | 2nd (2nd leg): 31/08/2010 23:45 | Winner: Oriente Petrolero | ||||
