 |
 |
|
| 1st(1st leg) | Danubio | - | Club Olimpia | 0:0 (0:0) | ||
| 2nd (2nd leg) | Club Olimpia | - | Danubio | 2:1 (2:1) | ||
| 1st(1st leg): 24/07/2012 23:15 | 2nd (2nd leg): 08/08/2012 01:45 | Winner: Club Olimpia | ||||
| 1st(1st leg) | Tacuary | - | Cobreloa | 0:1 (0:0) | ||
| 2nd (2nd leg) | Cobreloa | - | Tacuary | 2:2 (1:0) | ||
| 1st(1st leg): 25/07/2012 01:30 | 2nd (2nd leg): 07/08/2012 23:15 | Winner: Cobreloa | ||||
| 1st(1st leg) | Liverpool | - | Universitario de Sucre | 3:0 (3:0) | ||
| 2nd (2nd leg) | Universitario de Sucre | - | Liverpool | 1:2 (0:0) | ||
| 1st(1st leg): 25/07/2012 23:15 | 2nd (2nd leg): 16/08/2012 23:00 | Winner: Liverpool | ||||
| 1st(1st leg) | Deportivo Táchira | - | Barcelona | 0:0 (0:0) | ||
| 2nd (2nd leg) | Barcelona | - | Deportivo Táchira | 5:1 (3:0) | ||
| 1st(1st leg): 26/07/2012 01:30 | 2nd (2nd leg): 08/08/2012 23:15 | Winner: Barcelona | ||||
| 1st(1st leg) | Guaraní | - | Oriente Petrolero | 0:1 (0:0) | ||
| 2nd (2nd leg) | Oriente Petrolero | - | Guaraní | 1:2 (0:1) | ||
| 1st(1st leg): 26/07/2012 23:15 | 2nd (2nd leg): 09/08/2012 23:45 | Winner: Guaraní | ||||
| 1st(1st leg) | Club Aurora | - | Cerro Largo | 2:1 (1:0) | ||
| 2nd (2nd leg) | Cerro Largo | - | Club Aurora | 0:0 (0:0) | ||
| 1st(1st leg): 27/07/2012 01:30 | 2nd (2nd leg): 14/08/2012 22:30 | Winner: Club Aurora | ||||
| 1st(1st leg) | O'Higgins | - | Cerro Porteño | 3:3 (1:1) | ||
| 2nd (2nd leg) | Cerro Porteño | - | O'Higgins | 4:0 (2:0) | ||
| 1st(1st leg): 27/07/2012 01:30 | 2nd (2nd leg): 09/08/2012 01:45 | Winner: Cerro Porteño | ||||
| 1st(1st leg) | Unión Comercio | - | Envigado FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Envigado FC | - | Unión Comercio | 2:0 (2:0) | ||
| 1st(1st leg): 31/07/2012 20:15 | 2nd (2nd leg): 16/08/2012 01:45 | Winner: Envigado FC | ||||
| 1st(1st leg) | Deportes Iquique | - | Nacional | 2:0 (1:0) | ||
| 2nd (2nd leg) | Nacional | - | Deportes Iquique | 4:0 (2:0) | ||
| 1st(1st leg): 31/07/2012 23:00 | 2nd (2nd leg): 15/08/2012 01:00 | Winner: Nacional | ||||
| 1st(1st leg) | Emelec | - | Universidad San Martín | 1:0 (0:0) | ||
| 2nd (2nd leg) | Universidad San Martín | - | Emelec | 1:1 (1:0) | ||
| 1st(1st leg): 01/08/2012 01:15 | 2nd (2nd leg): 22/08/2012 03:30 | Winner: Emelec | ||||
| 1st(1st leg) | Deportes Tolima | - | Deportivo Lara | 3:1 (2:0) | ||
| 2nd (2nd leg) | Deportivo Lara | - | Deportes Tolima | 0:0 (0:0) | ||
| 1st(1st leg): 01/08/2012 03:30 | 2nd (2nd leg): 17/08/2012 01:30 | Winner: Deportes Tolima | ||||
| 1st(1st leg) | Deportivo Quito | - | León de Huánuco | 1:0 (0:0) | ||
| 2nd (2nd leg) | León de Huánuco | - | Deportivo Quito | 2:3 (2:2) | ||
| 1st(1st leg): 01/08/2012 23:30 | 2nd (2nd leg): 23/08/2012 20:00 | Winner: Deportivo Quito | ||||
| 1st(1st leg) | Inti Gas | - | Millonarios | 0:0 (0:0) | ||
| 2nd (2nd leg) | Millonarios | - | Inti Gas | 3:0 (1:0) | ||
| 1st(1st leg): 02/08/2012 20:15 | 2nd (2nd leg): 15/08/2012 03:30 | Winner: Millonarios | ||||
| 1st(1st leg) | La Equidad | - | Mineros de Guayana | 0:1 (0:1) | ||
| 2nd (2nd leg) | Mineros de Guayana | - | La Equidad | 2:1 (1:1) | ||
| 1st(1st leg): 02/08/2012 23:15 | 2nd (2nd leg): 10/08/2012 02:15 | Winner: Mineros de Guayana | ||||
| 1st(1st leg) | Blooming | - | Universidad Católica | 1:1 (0:0) | ||
| 2nd (2nd leg) | Universidad Católica | - | Blooming | 3:0 (2:0) | ||
| 1st(1st leg): 03/08/2012 01:30 | 2nd (2nd leg): 10/08/2012 02:15 | Winner: Universidad Católica | ||||
| 1st(1st leg) | Monagas | - | Liga de Loja | 0:2 (0:1) | ||
| 2nd (2nd leg) | Liga de Loja | - | Monagas | 4:2 (1:1) | ||
| 1st(1st leg): 03/08/2012 01:30 | 2nd (2nd leg): 15/08/2012 23:15 | Winner: Liga de Loja | ||||
