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| 1st(1st leg) | Huracán | - | Defensor Sporting | 1:0 (0:0) | ||
| 2nd (2nd leg) | Defensor Sporting | - | Huracán | 0:0 (0:0) | ||
| 1st(1st leg): 21/10/2015 00:45 | 2nd (2nd leg): 27/10/2015 23:45 | Winner: Huracán | ||||
| 1st(1st leg) | Athletico Paranaense | - | Sportivo Luqueño | 1:0 (0:0) | ||
| 2nd (2nd leg) | Sportivo Luqueño | - | Athletico Paranaense | 2:0 (2:0) | ||
| 1st(1st leg): 21/10/2015 23:00 | 2nd (2nd leg): 28/10/2015 22:00 | Winner: Sportivo Luqueño | ||||
| 1st(1st leg) | River Plate | - | Chapecoense | 3:1 (1:1) | ||
| 2nd (2nd leg) | Chapecoense | - | River Plate | 2:1 (1:1) | ||
| 1st(1st leg): 22/10/2015 01:00 | 2nd (2nd leg): 29/10/2015 00:00 | Winner: River Plate | ||||
| 1st(1st leg) | Independiente | - | Santa Fe | 0:1 (0:0) | ||
| 2nd (2nd leg) | Santa Fe | - | Independiente | 1:1 (1:0) | ||
| 1st(1st leg): 23/10/2015 00:45 | 2nd (2nd leg): 30/10/2015 00:00 | Winner: Santa Fe | ||||
