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| 1st(1st leg) | Independiente Medellín | - | Cerro Porteño | 0:0 (0:0) | ||
| 2nd (2nd leg) | Cerro Porteño | - | Independiente Medellín | 2:0 (1:0) | ||
| 1st(1st leg): 19/10/2016 01:00 | 2nd (2nd leg): 26/10/2016 01:00 | Winner: Cerro Porteño | ||||
| 1st(1st leg) | Atlético Junior | - | Chapecoense | 1:0 (1:0) | ||
| 2nd (2nd leg) | Chapecoense | - | Atlético Junior | 3:0 (2:0) | ||
| 1st(1st leg): 20/10/2016 00:45 | 2nd (2nd leg): 27/10/2016 00:45 | Winner: Chapecoense | ||||
| 1st(1st leg) | Coritiba - PR | - | Atlético Nacional | 1:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Coritiba - PR | 3:1 (0:1) | ||
| 1st(1st leg): 20/10/2016 00:45 | 2nd (2nd leg): 27/10/2016 00:45 | Winner: Atlético Nacional | ||||
| 1st(1st leg) | San Lorenzo | - | Palestino | 2:0 (2:0) | ||
| 2nd (2nd leg) | Palestino | - | San Lorenzo | 1:0 (0:0) | ||
| 1st(1st leg): 21/10/2016 01:00 | 2nd (2nd leg): 28/10/2016 01:00 | Winner: San Lorenzo | ||||
