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| 1st(1st leg) | Defensa y Justicia | - | Banfield | 0:0 (0:0) | ||
| 2nd (2nd leg) | Banfield | - | Defensa y Justicia | 0:2 (0:0) | ||
| 1st(1st leg): 21/08/2018 23:30 | 2nd (2nd leg): 28/09/2018 01:15 | Winner: Defensa y Justicia | ||||
| 1st(1st leg) | San Lorenzo | - | Nacional | 3:1 (2:0) | ||
| 2nd (2nd leg) | Nacional | - | San Lorenzo | 2:0 (1:0) | ||
| 1st(1st leg): 22/08/2018 23:30 | 2nd (2nd leg): 26/09/2018 01:15 | Winner: Nacional | ||||
| 1st(1st leg) | LDU Quito | - | Deportivo Cali | 1:0 (1:0) | ||
| 2nd (2nd leg) | Deportivo Cali | - | LDU Quito | 3:1 (1:0, 1:0) pso | ||
| 1st(1st leg): 23/08/2018 01:45 | 2nd (2nd leg): 20/09/2018 01:45 | Winner: Deportivo Cali | ||||
| 1st(1st leg) | Santa Fe | - | Millonarios | 0:0 (0:0) | ||
| 2nd (2nd leg) | Millonarios | - | Santa Fe | 3:5 (0:0, 0:0) pso | ||
| 1st(1st leg): 19/09/2018 01:45 | 2nd (2nd leg): 03/10/2018 01:45 | Winner: Santa Fe | ||||
| 1st(1st leg) | Caracas FC | - | Athletico Paranaense | 0:2 (0:1) | ||
| 2nd (2nd leg) | Athletico Paranaense | - | Caracas FC | 2:1 (1:0) | ||
| 1st(1st leg): 19/09/2018 23:30 | 2nd (2nd leg): 03/10/2018 23:30 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Deportivo Cuenca | - | Fluminense RJ | 0:2 (0:1) | ||
| 2nd (2nd leg) | Fluminense RJ | - | Deportivo Cuenca | 2:0 (1:0) | ||
| 1st(1st leg): 20/09/2018 23:30 | 2nd (2nd leg): 04/10/2018 23:30 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | Bahia - BA | - | Botafogo - RJ | 2:1 (1:0) | ||
| 2nd (2nd leg) | Botafogo - RJ | - | Bahia - BA | 4:5 (2:1, 2:1) pso | ||
| 1st(1st leg): 21/09/2018 01:45 | 2nd (2nd leg): 04/10/2018 01:45 | Winner: Bahia - BA | ||||
| 1st(1st leg) | Atlético Junior | - | Colón de Santa Fe | 1:0 (0:0) | ||
| 2nd (2nd leg) | Colón de Santa Fe | - | Atlético Junior | 1:1 (0:0) | ||
| 1st(1st leg): 27/09/2018 01:15 | 2nd (2nd leg): 04/10/2018 23:30 | Winner: Atlético Junior | ||||
