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| 1st(1st leg) | Santa Fe | - | Deportivo Cali | 1:1 (1:1) | ||
| 2nd (2nd leg) | Deportivo Cali | - | Santa Fe | 1:2 (0:2) | ||
| 1st(1st leg): 24/10/2018 01:45 | 2nd (2nd leg): 31/10/2018 00:45 | Winner: Santa Fe | ||||
| 1st(1st leg) | Fluminense RJ | - | Nacional | 1:1 (1:0) | ||
| 2nd (2nd leg) | Nacional | - | Fluminense RJ | 0:1 (0:0) | ||
| 1st(1st leg): 24/10/2018 23:30 | 2nd (2nd leg): 31/10/2018 22:30 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | Bahia - BA | - | Athletico Paranaense | 0:1 (0:0) | ||
| 2nd (2nd leg) | Athletico Paranaense | - | Bahia - BA | 4:1 (0:1, 0:1) pso | ||
| 1st(1st leg): 25/10/2018 01:45 | 2nd (2nd leg): 01/11/2018 00:45 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Atlético Junior | - | Defensa y Justicia | 2:0 (0:0) | ||
| 2nd (2nd leg) | Defensa y Justicia | - | Atlético Junior | 3:1 (2:0) | ||
| 1st(1st leg): 26/10/2018 01:45 | 2nd (2nd leg): 02/11/2018 00:45 | Winner: Atlético Junior | ||||
