 |
 |
|
|
| 1st(1st leg) | Red Bull Bragantino | - | Libertad | 2:0 (1:0) | ||
| 2nd (2nd leg) | Libertad | - | Red Bull Bragantino | 1:3 (0:1) | ||
| 1st(1st leg): 22/09/2021 23:15 | 2nd (2nd leg): 29/09/2021 23:15 | Winner: Red Bull Bragantino | ||||
| 1st(1st leg) | Peñarol | - | Athletico Paranaense | 1:2 (1:1) | ||
| 2nd (2nd leg) | Athletico Paranaense | - | Peñarol | 2:0 (1:0) | ||
| 1st(1st leg): 24/09/2021 01:30 | 2nd (2nd leg): 01/10/2021 01:30 | Winner: Athletico Paranaense | ||||
